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（最終更新日：2024-05-14 10:06:38）   シミズ　ジュン   SHIMIZU JUN   清水　潤    所属   医学部医学科 免疫学・病害動物学    職種   特任教授

■ 学術雑誌 1. 総説・解説　 Innate immune responses in Behçet disease and relapsing 2023/06 2. 原著　 Evaluation of airway involvement and treatment in patients with relapsing polychondritis 2023/05 3. 総説・解説　 Chemokines and chemokine receptors as promising targets in rheumatoid arthritis 2023/02 4. 総説・解説　 清水潤, 村山正承, 鈴木登 2022/11 5. 総説・解説　 Immunopathology of Behcet's Disease: An Overview of the Metagenomic Approaches 2022/08 6. 総説・解説　 アレルゲン免疫療法の最新情報と将来展望 2022/07 7. 総説・解説　 Mechanical model of steady-state and inflammatory conditions in patients with relapsing polychondritis: A review. 2022/02 8. 原著　 Nationwide cross-sectional survey of patients with relapsing polychondritis in 2019 demonstrates reduction of airway involvement compared with that in 2009. 2022/01 9. 総説・解説　 ゲノム情報とオミックス情報を活用した「予防医学」,ヒト末梢血T細胞分化異常と腸内細菌叢変化の病理的関連検討 2021/12 10. 総説・解説　 ベーチェット病とマイクロバイオーム 2021/09 11. 原著　 Serum MMP3 Correlated With IL1β Messenger RNA Expressions of Peripheral Blood Mononuclear Cells in Patients With Relapsing Polychondritis With Respiratory Involvement 2021/07 12. 総説・解説　 神奈川県とダニ媒介感染症：ダニ媒介感染症の現状と隣接県との関連について 2021/07 13. 総説・解説　 食物アレルギー診療の動向, ヒト末梢血T細胞分化異常と腸内細菌叢変化の病理的関連検討 2021/07 14. 総説・解説　 ベーチェット病における腸内microbiomeと免疫機能偏倚 2021/06 15. 原著　 Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice. 2021/04 16. 原著　 Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunctions with neural cell transplantation 2021/04 17. 原著　 Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer's disease. 2021/04 18. 総説・解説　 その他の症状等から疑う希少疾患　再発性多発軟骨炎 2021/04 19. 症例報告　 Patient consultation in the Department of Immunology and Medical Zoology at St. Marianna University School of Medicine between 2001-2019 with an interest in parasitic diseases in Japan. J. St. Marianna Univ 2021/02 20. 原著　 Elucidation of predictors of disease progression in patients with relapsing polychondritis at the onset: potential impact on patient monitoring 2020/09 21. 原著　 Interaction between SDF1 and CXCR4 promotes photoreceptor differentiation via upregulation of NFkB pathway signalling activity in Pax6 gene transfected photoreceptor precursors 2020/01 22. 原著　 Interaction between SDF1 and CXCR4 Promotes Photoreceptor Differentiation via Upregulation of NFκB Pathway Signaling Activity in Pax6 Gene-Transfected Photoreceptor Precursors 2020/01 23. 原著　 Transplantation of Human iPS Cell-Derived Neural Cells with an Artificial Nerve Conduit Leads to Cellular Retention in the Transplanted Area and Improves Motor Function in a Mouse Spinal Cord Injury Model 2019/12 24. 原著　 研究者の最新動向　ヒト末梢血T細胞分化異常と腸内細菌叢変化の病理的関連検討 2019/04 25. 原著　 Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease. 2019/01 26. 原著　 Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts. 2019 27. 総説・解説　 ヒト末梢血T細胞分化異常と腸内細菌叢変化の病理的関連検討. 2019 28. 原著　 Relapsing polychondritis patients were divided into three subgroups: patients with respiratory involvement (R subgroup), patients with auricular involvement (A subgroup), and overlapping patients with both involvements (O subgroup), and each group had distinctive clinical characteristics. 2018/10 29. 原著　 Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis. 2018/09 30. 総説・解説　 Cellular and Molecular Mechanisms Governing Functional Recovery of Dementia Mice after Neuronal cell Transplantation. 2018/01 31. 総説・解説　 Organ involvement pattern suggests subgroups within relapsing polychondritis: comment on the article by Dion et al 2018/01 32. 原著　 ヒト末梢血T細胞分化関連遺伝子発現と腸内細菌叢の病理的関連検討 2017/11 33. 原著　 Neuronal cell sheet of cortical motor neuron phenotype derived from human iPS cells. 2017/08 34. 原著　 Human iPS cell derived neural cell sheets exhibit mature neural and extendable scaffold functions and promote recovery in injured mouse spinal cords. 2016/07 35. 原著　 Bifidobacteria Abundance-Featured Gut Microbiota Compositional Change in Patients with Behcet's Disease 2016/04 36. 原著　 Cardiac involvement in relapsing polychondritis in Japan 2016/03 37. 原著　 Cellular Transplantation as the Treatment of Alzheimer's Disease in Mouse Models 2016/03 38. 原著　 Cutaneous manifestations of patients with relapsing polychondritis: an association with extracutaneous complications. 2016/01 39. 総説・解説　 ヒトアレルギー・免疫疾患におけるTh17細胞異常と腸内細菌叢 Dysbiosis 2016/01 40. 原著　 Enhanced Th17 responses with intestinal dysbiosis in human allergic, inflammatory, and autoimmune diseases 2016 41. 原著　 Possible association of proinflammatory cytokines including IL1β and TNFα with enhanced Th17 cell differentiation in patients with Behcet's disease. 2016 42. 原著　 Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells. 2015/09 43. 原著　 Induction of neural cells with spinal motoneuron phenotype from human iPS cells and the transplantation to totally transected spinal cords in mice. 2015/05 44. 原著　 Possible association of proinflammatory cytokines including IL1β and TNFα with enhanced Th17 cell differentiation in patients with Behcet's disease 2015/05 45. 原著　 Generation of Retinal Progenitor Cell Sheets which Differentiate into Rhodopsin Positive Photoreceptors from Mouse iPS Cell Derived Retinal Progenitor Cell Clones. 2015/02 46. 原著　 Pax7 Gene Induction Rapidly Regulates Myocyte Homeostasis in Human Induced Pluripotent Stem (iPS) Cells. 2014/12 47. 原著　 Neurological involvement of relapsing polychondritis in Japan: An epidemiologocal study. 2014/09 48. 原著　 Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. 2014/01 49. 原著　 A large-scale survey of patients with relapsing polychondritis in Japan. 2014 50. 原著　 Human iPS Cell Derived Neurons with Cortical Motor Neuron Phenotype are Relevant for Functional Recovery of Hemiplegic Mice with Injured Motor Cortex. 2013/12 51. 原著　 IGFII/Akt Signaling Regulates Myocyte Homeostasis in Human Induced Pluripotent Stem (iPS) Cells. 2013/12 52. 原著　 Transplantation of Motor Neurons Derived from Human iPS Cells into Total Transection Model of Spinal Cord Injury in Mice. 2013/12 53. 総説・解説　 ＜特集＞次世代健康・医療・福祉の化学　神経細胞シートを用いた脳血管疾患への移植応用 2013/01 54. 原著　 Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neurons derived from human iPS cells. 2013 55. 総説・解説　 Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcets Disease. 2013 56. 総説・解説　 稀な肺疾患　再発性多発軟骨炎． 2012/07 57. 原著　 Skewed TGFβ/Smad signaling pathway of T cells in patients with Behçet's disease. 2012/05 58. 原著　 Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease. 2012/04 59. 総説・解説　 Aberrant activation of Heat Shock Protein 60/65 reactive T cells in patients with Behcet's Disease. 2012 5件表示 全件表示(59件)

■ 学会発表 1. Gut microbe metabolite short-chain fatty acids may associate with development of respiratory involvement in patients with relapsing polychondritis. （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2022/11/10 2. IL1β mRNA expressions in peripheral blood mononuclear cells increase and may associate with cartilage damage of the respiratory tract probably through matrix metalloproteinase-3 production in patients with relapsing polychondrit. （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2021/06 3. Comparison of nation-wide epidemical study on 2009 and that on 2019 revealed that improvement of disease severity and mortality rate may come from progress of proficient management in patients with relapsing polychondritis in Japan. （ポスター，一般） 2020/11/06 4. 全切断脊髄損傷モデルへの人工神経導管併用神経幹細胞移植の治療効果 （ポスター，一般） 2020/10/15 5. A Third of Relapsing Polychondritis Patients Ear Involvement at Presentation. Had Airway Involvement at the Last Follow-up with a high Mortality Rate （口頭発表，一般） 2019/11/08 6. 完全離断脊髄損傷マウスモデルに対する神経再生誘導チューブ併用ヒトiPS細胞由来神経幹/前駆細胞移植の検討 （ポスター，一般） 2019/10/17 7. MOTOR FUNCTION RECOVERY IN HEMIPLEGIC MICE AFTER NEURAL STEM / PROGENITOR CELLS TRANSPLANTATION （ポスター，一般） 2019/06/26 8. 認知症モデルマウスを用いたヒトiPS由来神経細胞移植による認知機能改善における心理症状の評価と関連 （口頭発表，一般） 2019/05/15 9. 再発性多発軟骨炎は気道軟骨炎および耳介軟骨炎の有無により2群に分類される （ポスター，一般） 2019/04/26 10. 再発性多発軟骨炎における軌道軟骨炎・耳介軟骨炎の有無による群間検討の重要性 （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2019/04/17 11. Neural regeneration after transplantation of Neuronal cell sheet of cortical motor neuron phenotype （ポスター，一般） 2018/09/06 12. A STUDY ON THE IMPORTANCE OF REGENERATION OF GABAERGIC NEURONS IN RESTORING COGNITIVE FUNCTION BY HIPS DERIVED NEURAL CELL TRANSPLANTATION TO DEMENTIA MODEL MICE （ポスター，一般） 2018/06/20 13. NEURAL REGENERATION MECHANISMS IN TRANSPLANTATION OF NEURONAL CELLS DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS WITH THE EFFECT OF THEIR PARACRINE SECRETION （ポスター，一般） 2018/06/20 14. 再発性多発軟骨炎で認められた特徴的な腸内細菌叢と免疫異常　健常人およびベーチェット病と比較して （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2018/04/26 15. Reelin Signal Activation is Associated With Motor Function Recovery in the Neuron Transplantation of Hemiplegic Mice. （ポスター，一般） 2018/01/16 16. 脳損傷マウスに対する幹細胞由来神経細胞移植による神経再生 （ポスター，一般） 2016/12/02 17. RESTORATION OF HUMAN APP TRANSGENIC MOUSE COGNITIVE DYSFUNCTION AFTER TRANSPLANT OF HUMAN IPS CELL-DERIVED NEURAL STEM/PRECURSOR CELLS （ポスター，一般） 2016/06/25 18. 再発性多発軟骨炎（RP)における皮膚病変と皮膚外合併症との関連検討（多施設アンケート調査） （シンポジウム・ワークショップ・パネルディスカッション等） 2016/04/22 19. ヒトiPS細胞を用いた骨格筋細胞への分化誘導 （ポスター，一般） 2015/10/22 20. Human iPS derived neural stem/precursor improved spatial memory learning of dementia model mice. （ポスター，一般） 2015/06/25 21. ヒトiPS細胞から誘導した神経細胞移植による認知機能の改善とそのメカニズムについての検討 （ポスター，一般） 2015/06/05 22. 再発性多発軟骨炎（RP)の血管病変（多施設アンケート調査） （口頭発表，シンポジウム・ワークショップ・パネルディスカッション等） 2015/04/24 23. ヒトiPS由来神経細胞移植による空間記憶能の改善と改善メカニズムについての検討. （ポスター，一般） 2015/03/20 24. ヒトPax7遺伝子導入によるヒトiPS細胞から骨格筋細胞の分化誘導 （ポスター，一般） 2014/10/09 25. 脊髄全切断マウスにおけるヒトiPS細胞由来神経細胞移植後脊髄再生メカニズム （口頭発表，一般） 2014/10/09 26. IL-12/23 and the receptor involvement in helper T cell differentiation in patients with Behcet's disease (BD). （ポスター，一般） 2014/09/18 27. Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from hIPS cells. （ポスター，一般） 2014/06/19 28. ヒトiPS細胞から誘導した神経細胞移植による空間機能の改善と改善メカニズムの検討. （ポスター，一般） 2014/03 29. ヒトiPS細胞由来神経前駆細胞の運動神経分化誘導と脳損傷モデルマウスへの移植応用 （口頭発表，一般） 2013/07/05 30. Differentiation of cholinergic neurons from hiPS cells and restration of cognitive function by their transplantation in mice with dementia. （ポスター，一般） 2013/06 31. ヒトinduced pluripotent stem cell(hiPS)細胞からの皮質運動神経分化誘導. （ポスター，一般） 2013/03 32. ヒトiPS細胞由来神経細胞移植による認知症モデルマウスの認知機能改善効果の検討. （ポスター，一般） 2013/03 33. ヒト誘導多能性幹細胞の運動神経分化誘導と脳卒中モデルマウスへの移植応用 （ポスター，一般） 2012/10/19 34. T cell overactivation through TGFβ/Smad signalling pathway in patients with Behcet' s disease. （ポスター，一般） 2012/10 35. Experimental transplantation of human iPS cells derived neural cells in a mouse model of hemiplegia. （ポスター，一般） 2012/06 36. Transplantation of neural cells derived from human ips cells into an alzheimer's disease model. （ポスター，一般） 2012/06 37. ヒトiPS細胞の神経分化誘導と片麻痺モデルマウスへの移植. （ポスター，一般） 2012/06 38. ヒトiPS細胞由来神経細胞のアルツハイマー病モデルへの移植実験. （ポスター，一般） 2012/06 39. Strong TGF-beta and its receptor gene expressions in Behcet's disease.  2010/08 40. Unbalanced T cell response in Behçet's disease.  2010/07 41. ベーチェット病におけるT細胞抑制系シグナルの異常  2010/04 5件表示 全件表示(41件)