シノダ　カズノブ   SHINODA KAZUNOBU
  篠田和伸
   所属   医学部医学科 腎泌尿器外科学
   職種   教授
言語種別 日本語
発表タイトル Factors influencing intraoperative hypotension in PDD-TURBT with 5-aminolevulinic acid
会議名 第112回日本泌尿器科学会総会
学会区分 全国規模の学会
発表形式 ポスター掲示
講演区分 一般
発表者・共同発表者Aida Koichiro, Shimizu Takashi, Matsubara Keisuke, Morimoto Yuki, Shirai Daisuke, Tsukada Hikaru, Yoza Naoto, Iwata Teppei, Hayakawa Nozomi, Nakazawa Ryuto, Shinoda Kazunobu, Mizuno Ryuichi, Kikuchi Eiji
発表年月日 2025/04/18
開催地
（都市, 国名）		 福岡県福岡市
開催期間 2025/04/17～2025/04/19
概要 Background: Photodynamic Diagnosis (PDD) with 5-aminolevulinic acid (5-ALA) has been widely performed for the visualization of non-muscle invasive bladder cancer in recent years. However, intraoperative hypotension has been frequently reported as an adverse event following 5-ALA administration. This study aimed to examine the risk factors associated with intraoperative hypotension in patients undergoing PDD-TURBT with orally administered 5-ALA.
Methods: This study included seventy-nine patients who underwent PDD-TURBT for bladder tumors with 5-ALA under general anesthesia at St. Marianna University Hospital between July 2021 and August 2024. A decrease in systolic blood pressure of 60 mmHg or more was defined as hypotension, and subjects were divided into two groups based on this criterion. Clinical data, including age, gender, BMI, medical history, antihypertensive medications, and eGFR, were analyzed to identify risk factors associated with intraoperative blood pressure reduction.
Results: The mean age of the patients was 73.6 years, with 59 (74.7%) being male. Sixty patients (75.6%) were in the hypotensive group, with a mean systolic blood pressure of 86.6 mmHg and a range of 61-137 mmHg. The use of calcium channel blockers was identified as a significant risk factor for intraoperative hypotension (p=0.0065). Additionally, there was a trend toward lower eGFR in the hypotensive group (p=0.0771).
Conclusion: In patients undergoing PDD-TURBT with 5-ALA, the use of calcium channel blockers was found to be a predictor of intraoperative hypotension.

(c)2008 St. Marianna University School of Medicine