研究者情報

ヤマダ　ショウヘイ   YAMADA SHOHEI   山田将平    所属   医学部医学科 腎臓・高血圧内科    職種   助教
言語種別	英語
発表タイトル	Effect of Glucagon-like peptide-1, receptor agonist, liraglutide, against diabetic retinal edema in spontaneously diabetic tori fatty rats.
会議名	第126回日本解剖学会総会･全国学術集会・第98回日本生理学会大会 合同大会
学会区分	全国規模の学会
発表形式	ポスター掲示
講演区分	一般
発表者・共同発表者	Inoue K, Yamada S, Hosino S, Shibagaki Y, Ikemori A
発表年月日	2021/03/28
開催地 （都市, 国名）	Web開催
学会抄録	149 2021
概要	Background: The aim of this study is to investigate the effect of glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RA), liraglutide, against diabetic retinal edema using an animal model of type 2 diabetes. Methods: Male spontaneously diabetic torii (SDT) fatty rats at 8 weeks of age were randomly assigned to three groups; the liraglutide group has been subcutaneous injected liraglutide for 8 weeks. Other group was provided both insulin against hyperglycemia and hydralazine against hypertension for matching both levels of blood glucose and blood pressure with the liraglutide group. A control group was injected only a vehicle. Results: Control group exhibited hyperglycemia and hypertension, whereas two treatment groups similarly reduced both blood glucose and blood pressure levels. While retinal thickening for the retinal edema was found in control group, the degree was significantly prevented in the liraglutide group. Furthermore, the effect was also brought by the treatments of both insulin and hydralazine. Conclusions: Liraglutide prevented the retinal edema characterized in the early phase of diabetic retinopathy via reduction of both blood glucose and blood pressure levels.