研究者情報

スガヤ　タケシ   SUGAYA TAKESHI   菅谷　健    所属   医学部医学科 腎臓・高血圧内科    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Urinary liver-type fatty acid binding protein is a biomarker reflecting renal damage and the ameliorative effect of drugs at an early stage of histone-induced AKI.
掲載誌名	正式名：Nephrology 略　 称：Nephrology
掲載区分	国外
巻・号・頁	29(3),117-125頁
著者・共著者	Ohata Soichiro, Sugaya Takeshi, Nhung Nguyen Hanh, Arai Karin, Hatanaka Yuri, Uno Kinuko, Tohma Marika, Uechi Teppei, Sekiguchi Keita, Oikawa Tsuyoshi, Nagabukuro Hiroshi, Kuniyeda Kanako, Kamijo-Ikemori Atsuko, Suzuki-Kemuriyama Noriko, Nakae Dai, Noiri Eisei, Miyajima Katsuhiro
担当区分	2nd著者
発行年月	2024/03
概要	Aim: Circulated histones play a crucial role in the pathogenesis of infectious diseases and severe trauma, and it is one of the potential molecular targets for therapeutics. Recently, we reported that histone is one of the causative agents for urinary L-FABP increase. However, the mechanism is still unclear, especially in severe cases. We further investigated the mechanism of urinary L-FABP increase using a more severe mouse model with histone-induced kidney injury. This study also aims to evaluate the therapeutic responsiveness of urinary L-FABP as a preliminary study. Methods: Human L-FABP chromosomal transgenic mice were administrated 30mg/kg histone from a tail vein with a single dose. We also performed a comparative study in LPS administration model. For the evaluation of the therapeutic responsiveness of urinary L-FABP, we used heparin and rolipram. Results: The histological change with cast formation as a characteristic of the models was observed in proximal tubules. Urinary L-FABP levels were significantly elevated and these levels tended to be higher in those with more cast formation. Heparin and rolipram had the ameliorative effect of the cast formation induced by histone and urinary L-FABP levels significantly decreased. Conclusion: Histone is one of the causative agents for the increase of urinary L-FABP at an early stage of AKI. In addition, it suggested that urinary L-FABP may be useful as a subclinical AKI marker reflecting kidney damage induced by histone. Furthermore, urinary L-FABP reflected the degree of the damage after the administration of therapeutic agents such as heparin and PDE4 inhibitor.
DOI	10.1111/nep.14254
PMID	37950597