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研究者情報 |
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キクチ エイジ
KIKUCHI EIJI 菊地栄次 所属 医学部医学科 腎泌尿器外科学 職種 主任教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Long-term oncologic outcomes of laparoscopic versus open radical nephroureterectomy for patients with T3N0M0 upper tract urothelial carcinoma: a multicenter cohort study with adjustment by propensity score matching. |
| 掲載誌名 | 正式名：Annals of surgical oncology 略 称：Ann Surg Oncol ISSNコード：1534468110689265 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(11),3774-3781頁 |
| 著者・共著者 | Shigeta Keisuke, Kikuchi Eiji, Abe Takayuki, Hagiwara Masayuki, Ogihara Koichiro, Anno Tadanori, Umeda Kota, Baba Yuto, Sanjo Tansei, Shojo Kazunori, Mizuno Ryuichi, Oya Mototsugu |
| 担当区分 | 2nd著者 |
| 発行年月 | 2019/10 |
| 概要 | BACKGROUND:This study aimed to investigate the long-term oncologic outcomes oflaparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) for patients with clinical and pathologic T3N0M0 upper tract urothelial carcinoma (UTUC).METHODS:Among 375 UTUC patients who underwent radical nephroureterectomy, this study identified 144 pT3N0M0 patients as cohort 1 after propensity score (PS) matching. Among 399 UTUC patients, the study identified 110 cT3N0M0 patients as cohort 2 after PS matching. Oncologic outcomes such as intravesical recurrence-free survival (IVRFS) and cancer-specific survival (CSS) were assessed by multivariate Cox's regression analysis.RESULTS:Cohort 1 of pT3N0M0 UTUC had 3-year CSS and IVRFS rates of 67.9 and 52.7%, respectively, in the LRNU group, which were significantly lower than in the ORNU group (81.4%, p = 0.039 and 71.6%, p = 0.046). The multivariate Cox's regression analysis identified the type of surgical approach (LRNU vs. ORNU) as one of the independent prognostic factors for CSS (hazard rate [HR], 1.88, p = 0.043) and IVRFS (HR, 1.75, p = 0.049). Cohort 2 of cT3N0M0 UTUC had 3-year CSS and IVRFS rates of 48.5 and 41.4%, respectively, in the LRNU group, which were significantly lower than in the ORNU group (65.8%, p = 0.049 and 67.2%, p = 0.047), and the type of surgical approach (LRNU vs. ORNU) remained as one of the independent prognostic factors for CSS and IVRFS.CONCLUSIONS:Based on clinical and pathologic T3N0M0 UTUC populations after PS adjustments, LRNU resulted in poorer CSS and IVRFS than ORNU. |
| DOI | 10.1245/s10434-019-07623-1 |
| PMID | 31313043 |
