研究者情報

アカゾメ　ヤスヒサ   AKAZOME YASUHISA   赤染康久    所属   医学部医学科 解剖学（生物学）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Long-lasting redundant gnrh1/3 expression in GnRH neurons enabled apparent switching of paralog usage during evolution
掲載誌名	正式名：iScience 略　 称：iScience ISSNコード：25890042
掲載区分	国外
巻・号・頁	27(3),109304頁
著者・共著者	Chika Fujimori, Kohei Sugimoto, Mio Ishida, Christopher Yang, Daichi Kayo, Soma Tomihara, Kaori Sano, Yasuhisa Akazome, Yoshitaka Oka, and Shinji Kanda
発行年月	2024/03
概要	Expressed subtype of paralogous genes in functionally homologous cells sometimes show differences across species, the reasons for which have not been explained. The present study examined hypophysiotropic gonadotropin-releasing hormone (GnRH) neurons in vertebrates to investigate this mechanism. These neurons express either gnrh1 or gnrh3 paralogs, depending on the species, and apparent switching of the expressed paralogs in them occurred at least four times in vertebrate evolution. First, we found redundant expression of gnrh1 and gnrh3 in a single neuron in piranha and hypothesized that it may represent an ancestral GnRH system. Moreover, the gnrh1/gnrh3 enhancer of piranha induced reporter RFP/GFP co-expression in a single hypophysiotropic GnRH neuron in both zebrafish and medaka, whose GnRH neurons only express either gnrh3 or gnrh1. Thus, we propose that redundant expression of gnrh1/3 of relatively recent common ancestors may be the key to apparent switching of the paralog usage among present-day species.
DOI	10.1016/j.isci.2024.109304
PMID	38464591