研究者情報

オオヌマ　ヒロユキ   ONUMA HIROYUKI   大沼弘幸    所属   医学部医学科 整形外科学    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Comparison of the Efficacy of Two High-Molecular-Weight Hyaluronic Acid Products for Patients With Knee Osteoarthritis
掲載誌名	正式名：Orthopedics 略　 称：Orthopedics ISSNコード：01477447
掲載区分	国外
巻・号・頁	45(1),13-18頁
著者・共著者	Hiroyuki Onuma, Toshihiro Sugihara
発行年月	2022/01
概要	In Japan, hyaluronic acid (HA) is often used to treat patients with relatively mild knee osteoarthritis (OA). The use of HA in and the physique and lifestyle of the Japanese population differ from those of other populations. Therefore, clinical reports of HA from around the world must be interpreted with caution for application in Japan. We compared the clinical efficacy of two HA products, with average molecular weights of 900,000 (HA90) and 1.9 million (HA190), for Japanese patients with knee OA. There were 49 patients and 54 knees (27 patients received both HA90 and HA190 injections). We used a disease-specific/patient standing-type knee OA function evaluation scale that was developed earlier and later improved considering the uniqueness of the Japanese lifestyle. The assigned HA product was injected into the joints of patients with knee OA with Kellgren-Lawrence classification system grades I to III once a week, for 5 consecutive weeks. Effects were subjectively self-evaluated using the Japanese Knee Osteoarthritis Measure (JKOM) and a visual analog scale. The average age of the patients was 65.4 years (range, 42-88 years). Both HA products alleviated walking pain and improved JKOM scores, and symptoms continued to improve with continued injections for 6 months. The continued administration of HA90 improved general activity more than that of HA190. In contrast, HA190 improved initial pain more, but its continued administration did not contribute to improving general activity. These results suggest that it may be effective to use different HA products depending on the symptoms and conditions of patients with knee OA. [Orthopedics. 2022;45(1):13-18.].
DOI	10.3928/01477447-20211229-01
PMID	35040726