研究者情報

コジマ　シゲキ   KOJIMA SHIGEKI   小島茂樹    所属   医学部医学科 腎臓・高血圧内科    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Relationship Between Peritoneal Transport Characteristics and Natriuretic Peptides in Peritoneal Dialysis Patients.
掲載誌名	正式名：Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 略　 称：Adv Perit Dial ISSNコード：11978554
巻・号・頁	31,7-10頁
著者・共著者	◎Kojima S, Sakurada T, Uehara M, Okamoto T, Kaneshiro N, Konno Y, Shibagaki Y.
担当区分	筆頭著者
発行年月	2015
概要	Few studies have attempted to evaluate the relationship between peritoneal permeability and fluid status in peritoneal dialysis (PD). The aim of the present study was to clarify the relationship between change in the dialysate-to-plasma ratio of creatinine (D/P Cr) and change in fluid status as evaluated by natriuretic peptides. We studied 49 PD patients (29 men, 62 ± 11 years, 36.7% with diabetes) who underwent a peritoneal equilibration test at least twice after PD initiation. We evaluated correlations between the rate of change in the D/P Cr (R C-D/P Cr), the rate of change in a human atrial natriuretic polypeptide (RC-αhANP), and the rate of change in brain natriuretic peptide (RC-BNP). The RC-αhANP was strongly correlated with RC-BNP (r = 0.637, p < 0.001). In contrast, the RC-D/P Cr was not correlated with RC-αhANP (r = 0.041, p = 0.781) or with RC-BNP (r = 0.114, p = 0.435). However, positive correlations between RC-D/P Cr and RC-αhANP (r = 0.530, p = 0.006) and between RC-D/P Cr and RC-BNP (r = 0.625, p = 0.001) were observed in patients with increased D/P Cr The present study showed a positive correlation between change in peritoneal transport characteristics and change influid status in patients whose D/P Cr increased.