研究者情報

イノウエ　カズホ   INOUE KAZUHO   井上一歩    所属   医学部医学科 解剖学（機能組織）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effects of Empagliflozin Alone and in Combination with Exercise on the Soleus Muscle in Obese Type 2 Diabetic Rats.
掲載誌名	正式名：Journal of Physiological Sciences 略　 称：J Physiol Sci ISSNコード：13205358/14401797
掲載区分	国外
出版社名	ELSEVIER
巻・号・頁	Accepted頁
著者・共著者	Inoue K, Sekiguchi S, Ogura Y, Hoshino S, Katayama K, Asano J, Akagi T, Migitaka J, Watanabe S, Nagai Y, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
担当区分	筆頭著者
発行年月	2026/07
概要	This study assessed whether empagliflozin (EMPA) combined with endurance exercise further improves the soleus muscle in spontaneously diabetic Torii fatty rats, a model of obese type 2 diabetes. Male rats were divided into untreated control, exercise, EMPA, or EMPA + exercise groups. Age-matched Sprague–Dawley rats served as nondiabetic controls. Treadmill training and EMPA (0.03% in chow) were provided from 8 to 16 weeks of age. Both EMPA and the combined intervention improved blood glucose and insulin resistance. Additionally, the combined treatment reduced total cholesterol and triglycerides compared with EMPA alone. The cross-sectional area of type I fibers in the soleus tended to improve with all interventions. Combination treatment significantly enhanced citrate synthase activity, mitochondrial functional protein expression, and autophagic flux. These findings suggest that although EMPA does not adversely affect the soleus muscle, combining it with endurance exercise confers superior benefits via improved mitochondrial status, autophagy, and lipid metabolism.