研究者情報

シバガキ　ユウゴ   SHIBAGAKI YUGO   柴垣有吾    所属   医学部医学科 腎臓・高血圧内科    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Renoprotective effects of human L-type fatty acid-binding protein (hL-FABP) in rhabdomyolysis-induced acute kidney injury.
掲載誌名	正式名：Scientific Reports
掲載区分	国外
出版社名	NATURE PORTFOLIO
巻・号・頁	Online ahead of print.頁
著者・共著者	Inoue K, Hoshino S, Ohata K, Sugaya T, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
発行年月	2025/12
概要	L-type fatty acid-binding protein (L-FABP) in proximal tubules is reported to reduce oxidative stress. This study investigated whether renal L-FABP mitigated rhabdomyolysis (RM)-induced acute kidney injury (AKI). Wild-type (WT) mice, which lack renal L-FABP expression, and human L-FABP (hL-FABP) chromosomal transgenic (Tg) mice, which express hL-FABP in proximal tubules, were divided into RM (WT-RM, Tg-RM) and control (WT-Cont, Tg-Cont) groups. RM was induced via intramuscular injection of 50% glycerol/PBS into the quadriceps, whereas controls received PBS alone. On day 1, the WT-RM and Tg-RM groups exhibited similar increases in serum myoglobin, renal dysfunction, heme oxygenase-1 expression and tubulointerstitial damage. By day 3, the Tg-RM group demonstrated significant improvements in renal function, attenuation of tubulointerstitial damage, and decrease in macrophage infiltration compared with the WT-RM group. Lipid peroxidation marker 4-hydroxynonenal increased similarly in both RM groups on day 1, but its further elevation on day 3 was significantly suppressed in Tg-RM mice. Solute carrier family 7 member 11 on day 1 and glutathione peroxidase 4 on day 3 were significantly higher in Tg-RM mice than in WT-RM mice, which led to the suppression of ferroptosis. In conclusion, renal hL-FABP may prevent the progression of RM-induced AKI through ferroptosis inhibition by antioxidative effects.