研究者情報

シバガキ　ユウゴ   SHIBAGAKI YUGO   柴垣有吾    所属   医学部医学科 腎臓・高血圧内科    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of endurance exercise training on the kidneys of the senescence-accelerated mouse prone 8 model.
掲載誌名	正式名：Geriatrics & Gerontology International.
掲載区分	国外
出版社名	Wiley-Blackwell
巻・号・頁	accepted頁
著者・共著者	Inoue K, Hoshino S, Katayama K, Asano J, Akagi T, Ohata K, Sugaya T, Watanabe S, Kimura K, Shibagaki Y, Kamijo-Ikemori A.
発行年月	2025/12
概要	Aim: This study aimed to investigate the impact of endurance exercise training on kidney function in senescence-accelerated mouse prone 8 (SAMP8) mice. Methods: Thirty-week-old male SAMP8 mice were divided into two groups: one group underwent treadmill exercise for 10 weeks (Old-Ex group, n = 12), while the other group remained sedentary (Old-Cont group, n = 12). Additionally, a group of 8–10-week-old SAMP8 mice served as a young control (Young-Cont group, n = 22). Results: Although renal function was similar in the three groups, the renal mRNA expression of monocyte chemoattractant protein-1, macrophage infiltration, and collagen-type III-positive area in the interstitium were significantly higher in the Old-Cont group than in the Young-Cont group. However, these factors were significantly suppressed in the Old-Ex group. Renal protein expression of hypoxia-inducible factor-1α was significantly up-regulated in the Old-Cont group compared to the Young-Cont group but was significantly suppressed in the Old-Ex group. In terms of proteins related to mitochondrial function, renal protein expressions of peroxisome proliferator-activated receptor gamma coactivator 1α and medium-chain acyl-CoA dehydrogenase were comparable between the Old-Cont and Young-Cont groups but were significantly up-regulated in the Old-Ex group compared to the Old-Cont group. Renal protein expression of cytochrome c oxidase subunit 5B was significantly down-regulated in the Old-Cont group compared to the Young-Cont group, and this down-regulation was significantly restored by exercise. Conclusion: This study suggests that endurance exercise training may suppress renal interstitial inflammation and fibrosis in the kidneys of aged SAMP8 mice by preventing renal hypoxia and preserving mitochondrial function.