研究者情報

オオハタ　ケイイチ   OHATA KEIICHI   大畑敬一    所属   医学部医学科 腎臓・高血圧内科    職種   研究員
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Evaluation of serum L-FABP as a biomarker and hepatoprotective effect of L-FABP using wild-type and human L-FABP chromosome transgenic mice.
掲載誌名	正式名：Journal of the American Association for Laboratory Animal Science 略　 称：J Am Assoc Lab Anim ISSNコード：15596109
掲載区分	国外
出版社名	AMER ASSOC LABORATORY ANIMAL SCIENCE
巻・号・頁	accepted頁
著者・共著者	Ohata Keiichi, Ryu Kanjiro, Uno Kinuko, Teoh Soon Hui, Sugaya Takeshi, Kamijo-Ikemori Atsuko, Suzuki-Kemuriyama Noriko, Miyajima Katsuhiro
担当区分	筆頭著者,責任著者
発行年月	2025/04
概要	Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction- associated steatohepatitis (MASH) are the major prevalent liver diseases and growing public health problems worldwide. Because MASLD / MASH is known as a risk for progressing to cirrhosis and developing hepatocellular carcinoma, new therapeutic approaches and biomarkers that can reflect the presence and progression of the disease are expected to be developed. In recent years, the usefulness of serum L-FABP levels has been reported for monitoring hepatocellular damage in various liver diseases including MASLD / MASH in human. Furthermore, it is reported that L-FABP in the liver is a potential therapeutic target. The purpose of this study is to validate the usefulness of serum L-FABP as a liver damage biomarker in the mouse model of MASLD / MASH, and to evaluate the function of L-FABP in the pathogenesis of MASLD / MASH. Firstly, we evaluated the changes in serum L-FABP as a liver damage biomarker using a mouse model of MASLD / MASH fed a choline-deficient, methionine- lowered, amino acid-defined, high-fat diet. As a result, serum L-FABP levels in the MASLD / MASH model continuously increased with the progression of steatosis, and it correlated with the histopathological changes. Serum L-FABP may be useful biomarker for liver disease in aspect of translational research bridging between animal models and human clinical research. Secondly, we used the human L-FABP chromosomal transgenic mice and L-FABP had a suppressive effect on the gene expression associated with oxidative stress, fibrosis, and inflammation in the MASLD/MASH model. L-FABP is not only a biomarker in the blood but also has the functional aspect of hepatoprotection against MASLD / MASH.