研究者情報

シバガキ　ユウゴ   SHIBAGAKI YUGO   柴垣有吾    所属   医学部医学科 腎臓・高血圧内科    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Correlation of diabetic renal hypoperfusion with microvascular responses of the skeletal muscle: a rat model study using diffuse correlation spectroscopy
掲載誌名	正式名：Biomedical Optics Express
掲載区分	国外
出版社名	Optica Publishing Group
巻・号・頁	15(6),3900-3913頁
著者・共著者	Mikie Nakabayashi, Jun Tanabe, Yuji Ogura, Masashi Ichinose, Yugo Shibagaki, Atsuko Kamijo-Ikemori, and Yumie Ono
発行年月	2024/06
概要	Using diffuse correlation spectroscopy, we assessed the renal blood flow and thigh muscle microvascular responses in a rat model of type 2 diabetes. The blood flow index at the renal surface decreased significantly with arterial clamping, cardiac extirpation, and the progression of diabetic endothelial dysfunction. Renal blood flow measured in diabetic and nondiabetic rats also showed a significant correlation with the reactive hyperemic response of the thigh muscle. These results suggest shared microcirculatory dysfunction in the kidney and skeletal muscle and support endothelial responses in the skeletal muscle as a potential noninvasive biomarker of renal hypoperfusion.