イケモリ　アツコ   IKEMORI ATSUKO
  池森敦子
   所属   医学部医学科 解剖学（機能組織）
   職種   主任教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Correlation of diabetic renal hypoperfusion with microvascular responses of the skeletal muscle: a rat model study using diffuse correlation spectroscopy
掲載誌名 正式名：Biomedical Optics Express
掲載区分国外
出版社名 Optica Publishing Group
巻・号・頁 15(6),3900-3913頁
著者・共著者 Mikie Nakabayashi, Jun Tanabe, Yuji Ogura, Masashi Ichinose, Yugo Shibagaki, Atsuko Kamijo-Ikemori, and Yumie Ono
発行年月 2024/06
概要 Using diffuse correlation spectroscopy, we assessed the renal blood flow and thigh
muscle microvascular responses in a rat model of type 2 diabetes. The blood flow index at
the renal surface decreased significantly with arterial clamping, cardiac extirpation, and the
progression of diabetic endothelial dysfunction. Renal blood flow measured in diabetic and
nondiabetic rats also showed a significant correlation with the reactive hyperemic response of
the thigh muscle. These results suggest shared microcirculatory dysfunction in the kidney and
skeletal muscle and support endothelial responses in the skeletal muscle as a potential noninvasive
biomarker of renal hypoperfusion.

(c)2008 St. Marianna University School of Medicine