研究者情報

イケモリ　アツコ   IKEMORI ATSUKO   池森敦子    所属   医学部医学科 解剖学（機能組織）    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
招待論文	招待あり
表題	Clinical usefulness of urinary biomarkers for early prediction of acute kidney injury in patients undergoing transaortic valve implantation.
掲載誌名	正式名：Scientific Reports 略　 称：Sci Rep
掲載区分	国外
出版社名	NATURE PORTFOLIO
巻・号・頁	13,18569頁
著者・共著者	Obata Yumi, Kamijo-Ikemori Atsuko, Shimmi Sachi, Inoue Soichiro
担当区分	2nd著者
発行年月	2023/10
概要	This study aimed to reveal the clinical usefulness of urinary biomarkers for the early prediction of AKI onset after transcatheter aortic valve implantation (TAVI) (n = 173). In this study, 22 (12.7%) patients had AKI, of which 21 had mild AKI and 1 had moderate AKI. Higher levels of urinary liver-type fatty acid binding protein (L-FABP), [tissue inhibitor of metalloproteinases-2] × [insulin-like growth factor-binding protein 7], clusterin and urinary albumin before, after and 4 h after TAVI were associated with AKI onset. However, the time point of higher urinary N-acetyl-β-D-glucosaminidase levels related to AKI onset was only before TAVI. No significant differences were found in the area under the receiver-operator characteristic curves (AUC) for predicting AKI onset between urinary biomarkers before TAVI. After TAVI, the AUC (0.81) of urinary albumin was significantly higher than those of any other urinary biomarkers. The sensitivity (0.86) in urinary albumin after TAVI and specificity (0.98) in urinary L-FABP before TAVI were the highest among urinary biomarkers. In conclusion, urinary biomarkers may be clinically useful for early differentiation of patients with a higher or lower risk for AKI onset or early prediction of post-TAVI onset of AKI.
researchmap用URL	https://www.nature.com/articles/s41598-023-46015-0