研究者情報

オバタ　ユミ   OBATA YUMI   小幡由美    所属   医学部医学科 麻酔学    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
招待論文	招待あり
表題	Clinical usefulness of urinary biomarkers for early prediction of acute kidney injury in patients undergoing transaortic valve implantation.
掲載誌名	正式名：Scientific Reports 略　 称：Sci Rep
掲載区分	国外
出版社名	NATURE PORTFOLIO
巻・号・頁	13,18569頁
著者・共著者	Obata Yumi, Kamijo-Ikemori Atsuko, Shimmi Sachi, Inoue Soichiro
担当区分	筆頭著者,責任著者
発行年月	2023/10
概要	This study aimed to reveal the clinical usefulness of urinary biomarkers for the early prediction of AKI onset after transcatheter aortic valve implantation (TAVI) (n = 173). In this study, 22 (12.7%) patients had AKI, of which 21 had mild AKI and 1 had moderate AKI. Higher levels of urinary liver-type fatty acid binding protein (L-FABP), [tissue inhibitor of metalloproteinases-2] × [insulin-like growth factor-binding protein 7], clusterin and urinary albumin before, after and 4 h after TAVI were associated with AKI onset. However, the time point of higher urinary N-acetyl-β-D-glucosaminidase levels related to AKI onset was only before TAVI. No significant differences were found in the area under the receiver-operator characteristic curves (AUC) for predicting AKI onset between urinary biomarkers before TAVI. After TAVI, the AUC (0.81) of urinary albumin was significantly higher than those of any other urinary biomarkers. The sensitivity (0.86) in urinary albumin after TAVI and specificity (0.98) in urinary L-FABP before TAVI were the highest among urinary biomarkers. In conclusion, urinary biomarkers may be clinically useful for early differentiation of patients with a higher or lower risk for AKI onset or early prediction of post-TAVI onset of AKI.
researchmap用URL	https://www.nature.com/articles/s41598-023-46015-0