研究者情報

スガヤ　タケシ   SUGAYA TAKESHI   菅谷　健    所属   医学部医学科 腎臓・高血圧内科    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Mechanism for exercise-mediated prevention against muscle wasting on extensor digitorum longus muscle in Spontaneously Diabetic Torii fatty rats.
掲載誌名	正式名：Journal of Physiological Sciences 略　 称：J Physiol Sci
掲載区分	国外
出版社名	BMC
巻・号・頁	73(1),5頁
著者・共著者	Kotake Hitoshi, Ogura Yuji, Yamada Shohei, Inoue Kazuho, Watanabe Shiika, Ichikawa Daisuke, Sugaya Takeshi, Ohata Keiichi, Natsuki Yasunori, Hoshino Seiko, Watanabe Minoru, Kimura Kenjiro, Shibagaki Yugo, Kamijo-Ikemori Atsuko
発行年月	2023/04
概要	We previously reported the significant increase in limb muscle strength and cross-sectional area of the type IIb muscle fibers in the extensor digitorum longus (EDL) muscle in a type 2 diabetic animal model, with Spontaneously Diabetic Torii (SDT) fatty rats (n = 6) undergoing regular treadmill exercise from 8 to 16 weeks of age compared with sedentary SDT fatty rats (n = 6). This study investigated the mechanism by which exercise training prevented skeletal muscle wasting in the EDL muscle of the SDT fatty rats. The endurance exercise for 8 weeks downregulated the expression of muscle RING-finger protein-1 (an E3 ubiquitin ligase) and upregulated the expression of CD31, insulin receptor substrate-2, and phosphorylated endothelial nitric oxide synthase in the EDL muscle of 16-week-old SDT fatty rats. Endurance exercise training might reduce muscle wasting by preventing muscle degradation and increasing the angiogenic response in the EDL muscle in type 2 diabetes.