研究者情報

ヤマダ　ショウヘイ   YAMADA SHOHEI   山田将平    所属   医学部医学科 腎臓・高血圧内科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of GLP-1 Receptor Agonist, Liraglutide, on Muscle in Spontaneously Diabetic Torii Fatty Rats
掲載誌名	正式名：Molecular and Cellular Endocrinology 略　 称：Mol Cell Endocrinol
掲載区分	国外
出版社名	ELSEVIER
巻・号・頁	1(539),111472頁
著者・共著者	Yamada S, Ogura Y, Inoue K, Tanabe J, Sugaya T, Ohata K, Nagai Y, Natsuki Y, Hoshino S, Watanabe S, Ichikawa D, Kimura K, Shibagaki Y, Kamijo-Ikemori A
担当区分	筆頭著者
発行年月	2022/01
概要	This study investigated the effect of liraglutide, a glucagon-like peptide-1 receptor agonist, on skeletal muscles in rats with type 2 diabetes. Male SDT fatty rats (8-week-old) were provided liraglutide, or insulin-hydralazine for 8 weeks; control SDT fatty rats and SD rats were administered a vehicle. At 16 weeks of age, muscle strength of limbs was significantly lower in all SDT fatty rats compared to SD rats. While cross-sectional areas of type IIb muscle fibers in extensor digitorum longus muscle were significantly lower in SDT fatty rats than in SD rats, those of type I muscle fibers in soleus were similar in all rats. In the soleus of SDT fatty rats, liraglutide led to greater citrate synthase activity and cytochrome c oxidase subunit 5B protein expression, independently of blood glucose and blood pressure levels. Liraglutide may contribute to preservation of mitochondrial content on soleus muscle in type 2 diabetes.
DOI	10.1016/j.mce.2021.111472