研究者情報

ササキ　ヒデオ   SASAKI HIDEO   佐々木秀郎    所属   医学部医学科 腎泌尿器外科学    職種   客員教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation.
掲載誌名	正式名：Clinical and experimental nephrology 略　 称：Clin Exp Nephrol ISSNコード：1437779913421751
掲載区分	国外
巻・号・頁	24(2),174-184頁
著者・共著者	Soma Osamu, Hatakeyama Shingo, Yoneyama Tohru, Saito Mitsuru, Sasaki Hideo, Tobisawa Yuki, Noro Daisuke, Suzuki Yuichiro, Tanaka Masakazu, Nishimura Shin-Ichiro, Harada Hiroshi, Ishida Hideki, Tanabe Kazunari, Satoh Shigeru, Ohyama Chikara
発行年月	2020/02
概要	BACKGROUND:To evaluate whether serum N-glycan profile can be used as a diagnostic marker of graft rejection after living-donor kidney transplants (KT).METHODS:We retrospectively examined 174 KT recipients at five medical centers. N-Glycan levels were analyzed in postoperative serum samples using glycoblotting combined with mass spectrometry. We developed an integrated score to predict graft rejection based on a combination of age, gender, immunological risk factors, and serum N-glycan levels at post-KT day D1 and D7. Rejection-free survival rates stratified by the sum of integrated scores (D1 + D7) were evaluated using Kaplan-Meier curves.RESULTS:Of 174, 52 showed graft rejection (Rejection-pos. group) and 122 recipients did not show graft rejection (Rejection-neg. group). The integrated scores were significantly higher in the Rejection-pos. group than those of the Rejection-neg. group. Area-under-curve (AUC) value of integrated scores at post-KT D1, and D7 were 0.84 and 0.84, respectively. The sum of integrated scores (D1 + D7) ≥ 0.50 identified graft rejection with 81% sensitivity and 80% specificity; with an AUC value of 0.87. Recipients with higher sum of integrated scores (D1 + D7 ≥ 0.5) had significantly shorter rejection-free survival than those with lower scores.CONCLUSION:Evaluation of serum N-glycosylation profiles can identify recipients who are prone to rejection.
DOI	10.1007/s10157-019-01820-8
PMID	31768865