研究者情報

キクチ　エイジ   KIKUCHI EIJI   菊地栄次    所属   医学部医学科 腎泌尿器外科学    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer.
掲載誌名	正式名：Cancer science 略　 称：Cancer Sci ISSNコード：1349700613479032
掲載区分	国外
巻・号・頁	110(4),1431-1441頁
著者・共著者	Ogihara Koichiro, Kikuchi Eiji, Okazaki Shogo, Hagiwara Masayuki, Takeda Toshikazu, Matsumoto Kazuhiro, Kosaka Takeo, Mikami Shuji, Saya Hideyuki, Oya Mototsugu
担当区分	2nd著者
発行年月	2019/04
概要	The prognostic role of CD44v9, a variant isoform of CD44 and a new cell surface marker of cancer stem cells, remains unclear in bladder cancer (BC) patients. Furthermore, limited information is available on the functional role of sulfasalazine (SSZ), which could modulate the CD44v9-xCT system in order to enhance cisplatin (CDDP)-induced cytotoxicity and inhibit the metastatic potential of BC. CD44v9 protein expression was examined immunohistochemically in 63 muscle invasive BC (MIBC) patients who underwent radical cystectomy. CD44v9 expression was independently associated with disease recurrence and cancer-specific death in MIBC. Cytotoxic effects, glutathione levels, and reactive oxygen species production by SSZ and CD44v9 and phospho-p38MAPK
DOI	10.1111/cas.13960
PMID	30719824