研究者情報

シバガキ　ユウゴ   SHIBAGAKI YUGO   柴垣有吾    所属   医学部医学科 腎臓・高血圧内科    職種   主任教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Hyponatremic Chloride-depletion Metabolic Alkalosis Successfully Treated with High Cation-gap Amino Acid.
掲載誌名	正式名：Internal Medicine.
巻・号・頁	55(13),1765-1767頁
著者・共著者	Ryuge A, Matsui K, Shibagaki Y.
発行年月	2016/07
概要	Chloride (Cl)-depletion alkalosis (CDA) develops due to the loss of Cl-rich body fluid, i.e., vomiting or diuretics use, and is typically treated with a chloride-rich solution such as normal saline (NS). Although NS is one of the most utilized Cl-rich solutions, high cation-gap amino acid (HCG-AA) predominantly comprises Cl and less sodium, making HCG-AA more efficient in correcting CDA. We herein report a case of CDA with chronic hyponatremia after frequent vomiting, which was successfully treated with HCG-AA without overcorrecting hyponatremia or causing hypervolemia. HCG-AA may be more beneficial than NS for treating hyponatremic or hypervolemic metabolic alkalosis.
PMID	27374680