ヒトミ　トシアキ   HITOMI TOSHIAKI
  人見敏明
   所属   医学部医学科 予防医学
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Neonicotinoid concentrations in urine from chronic kidney disease patients in the North Central Region of Sri Lanka.
掲載誌名 正式名：Journal of occupational health
略　 称：J Occup Health
ISSNコード：13419145/13489585
掲載区分国内
巻・号・頁 58,128-133頁
著者・共著者 Kabata R, Nanayakkara S, Senevirathna S, Harada KH, Chandrajith R, Hitomi T, Abeysekera T, Takasuga T, Koizumi A
発行年月 2016
概要 OBJECTIVES: Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed.
METHODS: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples. We selected 40 samples, 10 from farmers with CKDu and 10 from controls from each of two areas, Medawachchiya and Girandurukotte.
RESULTS: Imidacloprid and desmethyl-acetamiprid were found at significantly higher concentrations in the control samples (with medians of 51 ng/l and 340 ng/l, respectively) than in the CKDu samples (medians of 15 ng/l and 150 ng/l, respectively) when the results were not adjusted for the creatinine contents. None of the six compounds that were measured in the urine samples were found at significantly higher concentrations in the CKDu samples than in the control samples. None of the neonicotinoid concentrations in the samples analyzed in this study exceeded the concentrations that have been found in samples from the general population of Japan.
CONCLUSIONS: Farmers (both with and without CKDu) living in CKDu-endemic areas in the NCR of Sri Lanka are exposed to lower neonicotinoid concentrations than non-occupationally exposed residents of Japan.
DOI 10.1539/joh.15-0140-BR

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